Нанотехнології у фармації

Нанотехнологія — нова галузь науки та виробництва, яка переживає бурхливий розвиток. Вчені у всьому світі працюють над створенням нових наноматеріалів, більше ніж у 40 країнах існують спеціальні програми, присвячені наносистемам і нанотехнологіям. Досягнення нанотехнології за останні роки позначились на всіх напрямах науки, в тому числі на розвитку медицини і фармації. Однак якщо в інших галузях — електроніці, авіації, космонавтиці, інформаційних технологіях — уже спостерігається перехід від фундаментальної науки до комерційного продукту, то в медицині та фармації зроблено лише перші кроки до створення інноваційних лікарських засобів. Які саме? Про це редакція запитала у Світлани Білоус, канд. фарм. наук, доцента кафедри технології ліків і біофармації Львівського національного медичного університету ім. Данила Галицького

— Світлано Богданівно, Ваші наукові дослідження присвячені нанотехнологіям у фармації. Чим зумовлений вибір цього напряму?

Cвітлана Білоус
Cвітлана Білоус (фото: Ігор Садовий)

— Нанотехнології у фармації є вимогою сьогодення. Їхнє впровадження відбувається в усіх напрямах науки, в тому числі в медицині і фармації, де наноматеріали (матеріали розміром до 100 нм [1 нм=10-9 м]) знаходять своє застосування в діагностиці та лікуванні різних захворювань.

Нанотехнології у фармації — це перш за все створення ліків з нанорозмірними матеріалами, які в їхньому складі можуть виконувати функції активних фармацевтичних інгредієнтів, допоміжних речовин або матеріалів для упакування.

— Якими є досягнення вчених в Україні з нанотехнологій у медичній сфері?

— Характеризуючи стан досліджень в Україні, можна стверджувати, що вітчизняні науковці активно створюють наноматеріали для медицини, так звані біоматеріали. Над створенням наноматеріалів для потреб медицини працює низка науково-дослідних установ НАН та НАМН України і навчальних закладів різного профілю. З цією метою застосовується багато методів: газовий і плазмохімічний синтез, електронно-променева технологія, термічне розкладання та відновлення, електровибух тощо. Однак треба відзначити, що нині в Україні ведеться ґрунтовна робота щодо створення потенційних активних речовин, які можуть бути використані при розробці лікарських засобів, тобто наноматеріали стали об’єктами досліджень хіміків, фізиків і біохіміків, а за останні роки також фармакологів і токсикологів. Зокрема, проведені дослідження під керівництвом академіка НАН України Ю.І.  Кундієва, академіка НАМН України І.М. Трахтенберга, чл.-кор. НАН України І.С. Чекмана та інших. Щодо технологів, які задіяні у створенні лікарських засобів, то у цьому напрямі зроблено лише перші кроки.

Сподіваємось, що активність досліджень зростатиме. Останнім часом при розробці нових ліків все частіше як об’єкти досліджень розглядають речовини, одержані за допомогою методів нанотехнологій. Такі дослідження активізувались із затвердженням Державної цільової науково-технічної програми «Нанотехнології та наноматеріали» на 2010–2014 рр.

— Які інновації можуть запропонувати львівські науковці?

— На кафедрі технології ліків і біофармації ЛНМУ ім. Данила Галицького проводяться дослідження з фармацевтичної розробки лікарських засобів з наночастинками металів. Наночастинки металів, зокрема срібла, міді та інші, які мають антимікробну активність, представляють важливий інтерес, оскільки сьогодні надзвичайного гостро у медицині стоїть питання боротьби з явищем  резистентності мікроорганізмів до протимікробних препаратів. Особливе занепокоєння резистентність викликає в тих країнах, де порушуються правила відпуску і застосування антибіотиків. На жаль, таку ситуацію маємо і в Україні. Враховуючи дані досліджень, описані у зарубіжній літературі, а також результати досліджень, проведених у нашій країні, що свідчать про ефективність наночастинок срібла, міді та інших металів проти цілої низки аеробних, анаеробних, грампозитивних та грамнегативних бактерій, дріжджових грибів, нитчастих грибів і вірусів, а також відсутність виникнення резистентності до них з боку мікроорганізмів, їхнє застосування виглядає досить перспективним. Срібло застосовують у клінічній практиці як антимікробний засіб вже понад століття, однак останніми роками інтерес до його використання як антимікробного агента суттєво зріс, особливо активно досліджуються препарати на його основі для лікування різних ран. Об’єктами наших досліджень є нанокомпозиції зазначених металів, одержані з використанням:
— методу електронно-променевих нанотехнологій, розроблених в лабораторії «Електронно-променевої нанотехнології неорганічних матеріалів для медицини» Інституту електрозварювання ім. Є.О. Патона;
— методу колоїдно-хімічного синтезу, розробленому в Інституті біоколоїдної хімії ім. Ф.Д. Овчаренка НАН України.
За фізико-хімічними властивостями досліджувані нанокомпозиції є наноструктурованими порошками та колоїдними розчинами.

— Нанотехнології у сьогоднішній практичній фармації це реальність чи радше справа далекого майбутнього?

— У практичну фармацію, зокрема в аптеки, нанотехнології запроваджуються наразі не через лікарські засоби, а через вироби медичного призначення та косметичні продукти. Це пов’язано з вимогами до проведення досліджень з розробки та реєстрації даних груп аптечних товарів.

Щодо ЛЗ, то наночастинки мають інші властивості порівняно з мікрооб’єктами, тому фармацевтична розробка препаратів, що їх містять, потребує особливих підходів до проведення досліджень.

Враховуючи, що нанорозмірні активні фармацевтичні інгредієнти є новими ліками не лише в Україні, але й у світовій фармації, не маючи достатнього підтвердження їхньої ефективності та безпеки, важливими є дослідження особливостей їхнього проникнення через біологічні мембрани, накопичення в паренхіматозних органах та виведення з організму. Наночастинки належать до тих діючих речовин, які потребують ретельних доклінічних досліджень — фармакологічних, мікробіологічних і токсикологічних.

Хоча об’єкти досліджень з фармацевтичної розробки є однаковими для всіх лікарських засобів, особливості досліджень препаратів із наноматеріалами пов’язані передовсім з тим, що створені різними розробниками з допомогою різних методів наноматеріали для медицини, в тому числі і наночастинки металів, за структурою є надзвичайно різними. Це нанопористі структури, нанодисперсії (колоїди), наноструктуровані поверхні, нанокристали, нанокластери тощо. До їх складу входять як неорганічні, так і органічні сполуки. Під терміном «наночастинка» металу, наприклад срібла, треба розуміти складну структуру, яка може містити поряд з молекулою активного інгредієнта допоміжні компоненти, які беруть участь у структуроутворенні. З огляду на це, наночастинки металів залежно від структури мають різні фізико-хімічні та технологічні властивості, зокрема, різну розчинність, розмір та форму частинок, фармакологічну активність, токсичність, що, своєю чергою, буде впливати на вибір складу, спосіб включення до лікарської форми та вибір аналітичного методу дослідження.

Відповідно до Державної фармакопеї України (ДФУ) для активних фармацевтичних інгредієнтів та допоміжних речовин, які застосовуються для розробки готових лікарських засобів, мають бути встановлені всі показники якості, які регламентуються вимогами загальної монографії  ДФУ  «Субстанції для фармацевтичного застосування», та розроблені методи контролю якості, затверджені уповноваженим органом. Актуальними проблемами створення лікарських засобів з наноматеріалами є те, що на сьогодні розробники наноматеріалів переважно не можуть представити технологам так званий Drug Master File на нанорозмірні субстанції. Тому на даному етапі одним з першочергових завдань для розробників наноматеріалів для медицини є опрацювання методів контролю якості субстанцій, що дасть можливість активізувати дослідження зі створення ліків на їхній основі.

— Спеціалісти якого профілю здатні створити новий лікарський препарат на основі наноматеріалів?

— Створення лікарських засобів з наноматеріалами потребує інтегрованих знань не лише з фахових фармацевтичних дисциплін, але й інших наукових напрямів, зокрема, фізики, яка вивчає міжатомні та міжмолекулярні взаємодії, квантові ефекти тощо. При створенні ліків із нанорозмірними діючими речовинами необхідні також знання з екологічної безпеки, наприклад, для розробки методів утилізації продуктів нанотехнології.

Отже, створення лікарських засобів з нанорозмірними лікарськими речовинами висуває особливі вимоги до спеціалістів та потребує комплексних знань з наукових напрямів, які, на перший погляд, є незалежними. Використання такого комплексного підходу до розробки ліків із наноматеріалами, ймовірно, дозволить встановити, що не всі вони можуть стати інноваційними препаратами, але одержані результати будуть важливим як для розвитку науки, так і для потенційних виробників, для яких впровадження нових інноваційних ліків — це перш за все великий ризик. Це унеможливить появу односторонніх висновків як позитивного, так і негативного характеру щодо ефективності та безпеки нанопрепаратів.

Лариса Дедишина

«Фармацевт Практик» #01′ 2015

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  94. Among me and my husband we’ve owned a lot more MP3 gamers previously mentioned the years than I can rely, such as Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, and many others. But, the closing handful of yrs I have solved down toward a person line of players. Why? Considering the fact that I was happy toward check out how well-designed and entertaining toward employ the service of the underappreciated (and commonly mocked) Zunes are.

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  119. This is getting a bit excess subjective, nevertheless I much favor the Zune Industry. The interface is colorful, consists of much more flair, and some neat functions including ‘Mixview’ that enable you quickly look at comparable albums, music, or other users comparable in the direction of what you happen to be listening towards. Clicking on 1 of those people will heart upon that products, and another mounted of «neighbors» will occur into belief, allowing your self in direction of navigate about studying through similar artists, audio, or buyers. Conversing of consumers, the Zune «Social» is also superior entertaining, letting your self identify many others with shared choices and turning into friends with them. Oneself then can listen to a playlist manufactured dependent on an amalgamation of what all your pals are listening in direction of, which is on top of that thrilling. Individuals apprehensive with privacy will be relieved in the direction of comprehend yourself can steer clear of the general public against observing your specific listening behavior if your self so pick out.

  120. Palms down, Apple’s app retailer wins by a mile. It really is a huge preference of all sorts of applications vs a really unsatisfied final decision of a handful for Zune. Microsoft consists of Ideas, especially inside the realm of video games, but I am not confident I would want toward guess upon the upcoming if this portion is major in direction of you. The iPod is a a great deal better preference inside of that situation.

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  123. Fingers down, Apple’s app retail outlet wins through a mile. It really is a substantial alternative of all sorts of purposes vs a pretty unsatisfied preference of a handful for Zune. Microsoft contains Ideas, especially in the realm of video games, still I’m not indeed I would need in direction of bet on the long term if this part is significant to yourself. The iPod is a much greater decision inside of that situation.

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  126. Arms down, Apple’s application store wins via a mile. It truly is a significant alternative of all styles of apps vs a rather unhappy decision of a handful for Zune. Microsoft has Designs, in particular in just the realm of games, yet I’m not positive I’d have to have in the direction of wager upon the potential if this aspect is major in direction of on your own. The iPod is a substantially superior choice inside that circumstance.

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  130. Involving me and my spouse we’ve owned even more MP3 gamers over the a long time than I can count, which include Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, and so on. But, the remaining few a long time I’ve fixed down towards one line of gamers. Why? Simply because I was content in the direction of come across how well-designed and exciting toward employ the service of the underappreciated (and commonly mocked) Zunes are.

  131. The contemporary Zune browser is remarkably Wonderful, yet not as Terrific as the iPod’s. It will work perfectly, nonetheless isn’t as instant as Safari, and includes a clunkier interface. If on your own at times system on employing the net browser that’s not an issue, nevertheless if you’re creating in the direction of examine the world-wide-web alot from your PMP then the iPod’s larger screen and improved browser could be necessary.

  132. In between me and my husband we’ve owned much more MP3 players about the many years than I can depend, such as Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the past pair yrs I’ve resolved down in direction of a single line of players. Why? Considering that I was content towards obtain how well-designed and exciting toward employ the service of the underappreciated (and broadly mocked) Zunes are.

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  134. Apple now is made up of Rhapsody as an app, which is a excellent get started, but it is currently hampered as a result of the inability towards retail outlet domestically on your iPod, and incorporates a dismal 64kbps little bit cost. If this adjustments, then it will to some degree negate this convenience for the Zune, however the 10 tunes per month will continue to be a big as well as inside of Zune Pass’ want.

  135. Apple at the moment has Rhapsody as an application, which is a suitable begin, still it is already hampered by means of the incapacity toward shop domestically on your iPod, and consists of a dismal 64kbps bit selling price. If this variations, then it will fairly negate this benefit for the Zune, nonetheless the Ten tunes for every month will even now be a significant moreover in just Zune Pass’ desire.

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  140. This is becoming a bit further subjective, yet I a lot like the Zune Industry. The interface is colorful, includes excess aptitude, and some awesome options like ‘Mixview’ that allow for on your own all of a sudden check out comparable albums, tunes, or other buyers equivalent in the direction of what you happen to be listening in the direction of. Clicking on a single of all those will heart upon that item, and yet another preset of «neighbors» will occur into view, allowing for yourself in direction of navigate close to exploring by means of identical artists, audio, or people. Talking of users, the Zune «Social» is too excellent fun, enabling by yourself locate other folks with shared choices and starting to be pals with them. Oneself then can pay attention towards a playlist generated based mostly on an amalgamation of what all your friends are listening to, which is moreover fascinating. Individuals concerned with privacy will be relieved in direction of understand your self can protect against the community in opposition to observing your individual listening routines if yourself therefore select.

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  560. Today, I went to the beach with my children. I found a sea shell and gave it to my 4 year old daughter and said «You can hear the ocean if you put this to your ear.» She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is completely off topic but I had to tell someone!

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  645. Hi! Do you know if they make any plugins to safeguard against hackers? I’m kinda paranoid about losing everything I’ve worked hard on. Any suggestions?

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  648. Currently it seems like Expression Engine is the best blogging platform out there right now. (from what I’ve read) Is that what you are using on your blog?

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  654. Hello there! I know this is somewhat off topic but I was wondering which blog platform are you using for this site? I’m getting sick and tired of WordPress because I’ve had issues with hackers and I’m looking at options for another platform. I would be fantastic if you could point me in the direction of a good platform.

  655. When I originally commented I clicked the «Notify me when new comments are added» checkbox and now each time a comment is added I get three e-mails with the same comment. Is there any way you can remove people from that service? Thank you!

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  662. Hi! This is kind of off topic but I need some guidance from an established blog. Is it hard to set up your own blog? I’m not very techincal but I can figure things out pretty fast. I’m thinking about setting up my own but I’m not sure where to begin. Do you have any tips or suggestions? Thanks

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  667. Hi there! I just wanted to ask if you ever have any trouble with hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work due to no backup. Do you have any methods to prevent hackers?

  668. I am really enjoying the theme/design of your website. Do you ever run into any browser compatibility problems? A handful of my blog audience have complained about my blog not working correctly in Explorer but looks great in Firefox. Do you have any ideas to help fix this problem?

  669. First of all I want to say great blog! I had a quick question in which I’d like to ask if you don’t mind. I was curious to find out how you center yourself and clear your mind prior to writing. I’ve had a hard time clearing my mind in getting my thoughts out there. I truly do take pleasure in writing but it just seems like the first 10 to 15 minutes are generally wasted simply just trying to figure out how to begin. Any ideas or tips? Kudos!

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  674. Hmm is anyone else having problems with the images on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog. Any suggestions would be greatly appreciated.

  675. Hey there! I know this is kind of off topic but I was wondering if you knew where I could get a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

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  683. At this time it looks like BlogEngine is the preferred blogging platform out there right now. (from what I’ve read) Is that what you’re using on your blog?

  684. Hey there, I think your site might be having browser compatibility issues. When I look at your blog in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, awesome blog!

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  686. Good day! This is kind of off topic but I need some guidance from an established blog. Is it hard to set up your own blog? I’m not very techincal but I can figure things out pretty quick. I’m thinking about making my own but I’m not sure where to begin. Do you have any tips or suggestions? Many thanks

  687. I am curious to find out what blog platform you are working with? I’m having some minor security problems with my latest blog and I’d like to find something more safeguarded. Do you have any solutions?

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  692. Hello! Quick question that’s entirely off topic. Do you know how to make your site mobile friendly? My website looks weird when viewing from my iphone. I’m trying to find a theme or plugin that might be able to resolve this issue. If you have any recommendations, please share. Appreciate it!

  693. Hi! Do you use Twitter? I’d like to follow you if that would be ok. I’m absolutely enjoying your blog and look forward to new posts.

  694. Hey! I know this is kind of off topic but I was wondering if you knew where I could get a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having problems finding one? Thanks a lot!

  695. Have you ever thought about adding a little bit more than just your articles? I mean, what you say is important and everything. Nevertheless imagine if you added some great visuals or video clips to give your posts more, «pop»! Your content is excellent but with images and videos, this site could undeniably be one of the greatest in its field. Terrific blog!

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  700. My programmer is trying to convince me to move to .net from PHP. I have always disliked the idea because of the costs. But he’s tryiong none the less. I’ve been using Movable-type on a number of websites for about a year and am anxious about switching to another platform. I have heard good things about blogengine.net. Is there a way I can import all my wordpress content into it? Any help would be greatly appreciated!

  701. Good day! Do you know if they make any plugins to safeguard against hackers? I’m kinda paranoid about losing everything I’ve worked hard on. Any suggestions?

  702. When I originally commented I clicked the «Notify me when new comments are added» checkbox and now each time a comment is added I get four emails with the same comment. Is there any way you can remove people from that service? Many thanks!

  703. Hmm is anyone else encountering problems with the pictures on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog. Any responses would be greatly appreciated.

  704. Admiring the hard work you put into your website and detailed information you present. It’s great to come across a blog every once in a while that isn’t the same out of date rehashed material. Excellent read! I’ve bookmarked your site and I’m adding your RSS feeds to my Google account.

  705. I’m really enjoying the theme/design of your site. Do you ever run into any web browser compatibility problems? A small number of my blog readers have complained about my blog not operating correctly in Explorer but looks great in Firefox. Do you have any solutions to help fix this issue?

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  707. Hey there! I just wanted to ask if you ever have any issues with hackers? My last blog (wordpress) was hacked and I ended up losing many months of hard work due to no backup. Do you have any methods to prevent hackers?

  708. Whats up this is somewhat of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding skills so I wanted to get advice from someone with experience. Any help would be enormously appreciated!

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  711. When I originally commented I clicked the «Notify me when new comments are added» checkbox and now each time a comment is added I get several emails with the same comment. Is there any way you can remove people from that service? Thanks!

  712. Today, while I was at work, my cousin stole my apple ipad and tested to see if it can survive a thirty foot drop, just so she can be a youtube sensation. My iPad is now destroyed and she has 83 views. I know this is entirely off topic but I had to share it with someone!

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  714. Hi there would you mind sharing which blog platform you’re using? I’m going to start my own blog soon but I’m having a tough time deciding between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something completely unique. P.S Apologies for getting off-topic but I had to ask!

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  726. I am really enjoying the theme/design of your website. Do you ever run into any browser compatibility issues? A number of my blog audience have complained about my website not working correctly in Explorer but looks great in Safari. Do you have any advice to help fix this problem?

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